Luporal (Tegafur/Uracil)

Product Name: Luporal
Generic Name: Tegafur + Uracil

Description:
Luporal is an oral chemotherapy medication that contains Tegafur (a prodrug of 5-fluorouracil) and Uracil (which enhances the effect of Tegafur). This combination is used primarily for the treatment of colorectal cancer and sometimes other solid tumors. Tegafur is converted in the body to 5-FU, which disrupts cancer cell DNA synthesis, while Uracil helps increase its availability by inhibiting its breakdown.

Key Details:
✅ Form: Oral tablets or capsules
✅ Indications:

• Colorectal cancer (especially advanced or recurrent cases)

• Sometimes used in combination with other chemotherapy agents

✅ Mechanism of Action:

• Tegafur converts into active 5-fluorouracil (5-FU), which interferes with DNA synthesis in cancer cells.

• Uracil competitively inhibits the breakdown of 5-FU, enhancing its anticancer activity.

Usage Instructions:

• Take exactly as prescribed by your oncologist.

• Usually taken orally, with or without food, at regular intervals.

• Swallow tablets whole with water; do not crush or chew.

Common Side Effects:

• Nausea, vomiting

• Diarrhea

• Loss of appetite

• Fatigue

• Low blood cell counts (increasing infection risk, anemia)

Serious Warnings (seek medical help):

• Severe diarrhea or dehydration

• Mouth sores or ulcers

• Unusual bleeding or bruising

• Signs of liver or kidney problems

Important Notes:

• Regular blood tests are essential to monitor blood counts and organ function.

• Inform your doctor about all other medications you are taking.

• Use effective birth control during treatment, as the drug can harm an unborn baby.

• Avoid breastfeeding while on this medication.